The Gold Standard in Skin Regeneration
REJURAN® is a highly purified polynucleotide (PN) injectable treatment developed in South Korea, where it has become the gold standard for regenerative skin rejuvenation. Unlike treatments that fill or freeze, REJURAN® works differently, supporting your skin’s own repair processes to restore stronger, smoother and more resilient skin over time.
At Hestia, every REJURAN® treatment is carried out by experienced medical practitioners following a comprehensive consultation and advanced skin assessment. We don’t simply treat lines or wrinkles. We create personalised treatment plans designed to restore genuinely healthier skin.
What is REJURAN®?
REJURAN® contains highly purified polynucleotides (PN) — long-chain DNA fragments derived from salmon that act as a biological scaffold within the dermis. Unlike treatments that add volume or relax muscle movement, REJURAN® works at a cellular level, supporting your skin’s own repair processes to restore stronger, smoother and more resilient skin over time.
As we age, fibroblasts — the cells responsible for producing collagen, elastin and hyaluronic acid — gradually become less active. The result is skin that becomes progressively thinner, drier and less resilient, with a reduced ability to repair itself in response to daily environmental stress. By introducing highly purified polynucleotides directly into the dermis, REJURAN® creates the ideal biological environment for fibroblasts to function more effectively — encouraging the skin to restore what it has lost, naturally.
Research also suggests polynucleotides support wound healing, reduce inflammation and improve the extracellular matrix, creating healthier skin from within rather than simply improving its appearance on the surface.
Over the weeks following treatment, your skin gradually begins to:
✓ Produce more collagen
✓ Improve elasticity
✓ Increase hydration
✓ Strengthen the skin barrier
✓ Improve overall skin quality
Because these changes happen at a cellular level, results develop gradually and continue to improve over 6–12 weeks — offering genuine long-term skin health rather than a temporary cosmetic fix.
The result isn’t a different face. It’s healthier skin.
Treatment Areas
Full Face +
Improve overall skin quality, texture and elasticity across the entire face.
Full Face & Neck +
Improve overall skin quality, texture and elasticity across the face and neck in a single treatment session.
Under Eyes +
One of REJURAN®’s most popular treatment areas. The delicate skin around the eyes responds exceptionally well, with improvements in crepiness, fine lines and overall skin quality.
Scars +
Including acne scarring and selected surgical scars.
Polynucleotide FAQ’s
The treatment is generally well-tolerated. A numbing cream is applied beforehand to minimise discomfort, but you may still experience mild sensations during the injections.
For optimal results, a course of 2 sessions is generally recommended. Maintenance treatments may be required every 6–12 months, depending on individual needs. Your practitioner will provide personalised advice and recommend the ideal treatment plan based on your skin’s specific requirements.
Polynucleotide treatments are safe when performed by a qualified practitioner. They are biocompatible, meaning they are naturally absorbed by the body with minimal risk of allergic reactions or side effects. However, this treatment is not suitable for individuals with fish or shellfish allergies due to the origin of the polynucleotides.
There is minimal downtime. You may experience some redness, swelling, or mild bruising at the injection sites, which usually resolves within 48 hours. Most people can return to their normal activities immediately after the treatment.
After a polynucleotide treatment, avoid direct sun exposure, intense heat, and strenuous exercise for 24–48 hours. Refrain from touching or rubbing the treated area, and avoid applying makeup for at least 12 hours. It’s also best to steer clear of alcohol, blood thinners, and harsh skincare products like retinol or exfoliants for 5 days to prevent irritation and bruising. Always follow your practitioner’s aftercare instructions for optimal results.
Yes, polynucleotides can be combined with other treatments such as microneedling, PRP (platelet-rich plasma), or dermal fillers for enhanced results. It’s particularly great for combining with these treatments, as it helps to further stimulate collagen production and improve skin texture, providing more comprehensive and longer-lasting benefits.
